Divigel® gives women a convenient solution for relief of moderate to severe vasomotor symptoms due to menopause.

Divigel® is an estradiol gel that is invisible, odorless and non-sticky when dry. It delivers highly concentrated estradiol at 0.1%, so only a small amount of gel is applied once daily to the upper thigh.

#1 Prescribed Transdermal Estrogen Gel2

Divigel® eliminated nearly 90% of vasomotor symptoms in 12 weeks with 1 mg/day.3

Once-Daily Application
  • Once-daily application for all-day, all-night estradiol coverage.
  • Divigel® offers 4 dosage strengths, including the lowest FDA-approved dose (0.25 mg/day) of transdermal estradiol gel or spray for effective relief of moderate to severe hot flashes.8
Premeasured Packets
  • Divigel® comes in small packets that are portable, discreet, and easy to use at home or away.
  • Divigel® samples include one week of therapy and a travel case.
  • Divigel® is appropriate for active lifestyles and in hot and humid conditions, where patch adhesion can be problematic.
Concentrated and Easy to Apply
  • Divigel® is a concentrated gel that is applied to a small area on the upper thigh.
  • Alternate between left and right thigh each day.
Invisible Gel
  • Divigel® is a gel that leaves no sticky residue.
  • It’s invisible and odorless when dry. Nobody knows you’re wearing it.
  • To reduce the risk of transmission, advise patients to wash hands, avoid skin contact until gel is completely dried, and cover the application site.
Divigel® Offers Savings
  • Divigel® has broad coverage on most insurance plans and is one of the lowest cost non-patch topical estrogen therapies.9
  • Eligible patients can enroll in the Patient Savings Program to save on 12 months of Divigel®.

Current American Congress of Obstetricians and Gynecologists (ACOG) and North American Menopause Society (NAMS) guidelines recommend using the lowest effective dose of estrogen, for the shortest duration of time, for treatment of vasomotor symptoms.6,7 “Natural” or compounded estradiol products are NOT FDA-approved6.

Effective Relief


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1. Divigel® [package insert]. Vertical Pharmaceuticals, LLC; 2018.
2. This information is an estimate derived from the use of information under license from the following IQVIA information service: NPA™, for the period 2018. IQVIA expressly reserves all rights, including rights of copying, distribution and republication.
3. Hedrick RE, Ackerman RT, Koltun WD, Halvorsen MB, Lambrecht LJ. Transdermal estradiol gel 0.1% for the treatment of vasomotor symptoms in postmenopausal women. Menopause. 2009;16(1):132-140.
4. https://www.accessdata.fda.gov/scripts/cder/ob/search_product.cfm accessed April 27, 2018.
5. IMS data, April 2018.
6. The North American Menopause Society. The Menopause Guidebook. 8th ed. Mayfield Heights, OH: The North American Menopause Society; 2015.
7. American College of Obstetricians and Gynecologists. ACOG Releases Clinical Guidelines on Management of Menopausal Symptoms. Volume 90, Number 5. September, 2014. 8. https://www.accessdata.fda.gov/scripts/cder/ob/search_product.cfm accessed 4/27/18.
9. Data on file, Osmotica Pharmaceuticals 2018.

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