Who should not take Divigel®?

Do not start using Divigel® if you:
  • Have unusual vaginal bleeding
  • Currently have or have had certain cancers
    • Estrogens may increase the chances of getting certain types of cancers, including cancer of the breast or uterus (womb). If you have or have had cancer, talk with your healthcare professional about whether you should use Divigel®.
  • Had a stroke or heart attack
  • Currently have or had blood clots
  • Currently have or have had liver problems
  • Have been diagnosed with a bleeding disorder
  • Are allergic to Divigel® or any of its ingredients
    • See the list of ingredients in Divigel® at the end of the package insert.
Tell Your Doctor

About all of your medical conditions. Your healthcare provider may need to check you more carefully if you have certain conditions, such as asthma (wheezing), diabetes, epilepsy (seizures), migraine; endometriosis, lupus, angioedema (swelling of face and tongue), problems with your heart, liver, thyroid, kidneys, or have high calcium levels in your blood.

If you are breastfeeding, the hormone in Divigel® can pass into your breast milk.

Are there any potentially serious side effects with estrogen therapy, including Divigel®?

Yes serious, but less common side effects include:
  • Stroke
  • Blood clots
  • Heart attack
  • Cancer of the lining of the uterus (womb)
  • Breast cancer
  • Cancer of the ovary
  • Dementia
  • Gall bladder disease
  • High blood calcium (hypercalcemia)
  • High blood pressure
  • High triglyceride (fat levels in your blood)
  • Liver problems
  • Low thyroid levels in your blood
  • Fluid retention
  • Low blood calcium (hypocalcemia)
  • Enlargement of benign tumors of the uterus (“fibroids”)
  • Worsening of angioedema (swelling of face and tongue)
  • Changes in certain laboratory test results
  • High blood sugar
Call your healthcare professional right away if you get any of the following warning signs or any other unusual symptoms that concern you:
  • New breast lumps
  • Unusual vaginal bleeding
  • Changes in vision or speech
  • Sudden new severe headaches
  • Severe pains in your chest or legs with or without shortness of breath, weakness and fatigue