Do I need to take progestin with Divigel®?

That depends.
  • If you have not had a hysterectomy (and your uterus is intact), then the answer is probably yes. That’s because taking estrogen alone may increase the chance of cancer of the uterus (also known as uterine or endometrial cancer). Taking progestin helps reduce this risk. Your healthcare professional can help you make the right decisions and recommend the appropriate dose of progestin.
  • If you have had a hysterectomy (removal of the uterus), then the answer is probably no. After a hysterectomy, your healthcare professional may recommend that you take estrogen therapy without progestin.

How many times a day should I apply Divigel®?

Divigel® should be applied to the skin once a day, around the same time each day. You can choose to apply it at the time that is most convenient for you.

Because Divigel® should be applied to clean and dry skin, many women choose to apply it after their daily bath or shower or at night before bed. The application site should be completely dry before dressing.

Can I apply Divigel® to any part of my body?

No. Divigel® should only be applied to your upper thigh. You should alternate between your right and left thigh each day .
  • Application of Divigel® to other areas of the body, such as the arms or abdomen, has not been tested in clinical studies and, therefore, is not recommended.
  • Do not apply Divigel® to your face, breasts, or irritated skin. Never apply Divigel® in or around the vagina. Contact of the gel with the eyes should be avoided.
  • There is a potential risk for transdermal transmission of estradiol in Divigel® to another individual. To reduce the risk of transmission, cover the applied area until Divigel® has completely dried. Let the Divigel® dry and wash your hands before your thigh or hands touch someone else.