Are there any potentially serious side effects with estrogen therapy, including Divigel®?

Yes serious, but less common side effects include:
  • Stroke
  • Blood clots
  • Heart attack
  • Cancer of the lining of the uterus (womb)
  • Breast cancer
  • Cancer of the ovary
  • Dementia
  • Gall bladder disease
  • High blood calcium (hypercalcemia)
  • High blood pressure
  • High triglyceride (fat levels in your blood)
  • Liver problems
  • Low thyroid levels in your blood
  • Fluid retention
  • Low blood calcium (hypocalcemia)
  • Enlargement of benign tumors of the uterus (“fibroids”)
  • Worsening of angioedema (swelling of face and tongue)
  • Changes in certain laboratory test results
  • High blood sugar
Call your healthcare professional right away if you get any of the following warning signs or any other unusual symptoms that concern you:
  • New breast lumps
  • Unusual vaginal bleeding
  • Changes in vision or speech
  • Sudden new severe headaches
  • Severe pains in your chest or legs with or without shortness of breath, weakness and fatigue