Divigel® offers an estradiol gel in five dosing options for individualized treatment of moderate to severe vasomotor symptoms due to menopause:
Divigel® is the only estrogen therapy to offer the lowest FDA-approved transdermal estradiol gel or spray available at
0.25 mg/day.1
0.25 mg
0.5 mg
0.75 mg
1 mg
1.25 mg
Divigel® offers an estradiol gel in five dosing options for individualized treatment of moderate to severe vasomotor symptoms due to menopause:
Divigel® is the only estrogen therapy to offer the lowest FDA-approved transdermal estradiol gel or spray available at 0.25 mg/day.1
0.25 mg | 0.5 mg | 0.75 mg | 1 mg | 1.25 mg |
Divigel® is effective at reducing hot flashes2


This was a 12-week, randomized, double-blind, placebo-controlled clinical trial of 488 post-menopausal women who received 1 mg, 0.5 mg, or 0.25 mg of Divigel® or placebo gel daily.2 98.6% [481/488] of all patients had severe vasomotor symptoms at baseline.2
*0.5 mg/day is not statistically significant from placebo until week 4 and beyond, and week 5 and beyond 0.25/day.
- At the highest dose (1 mg/day) Divigel® eliminated nearly 9 out of 10 daily hot flashes by week 12.2
- As early as 2 weeks, Divigel® (1 mg/day) was shown to reduce the frequency of hot flashes by nearly HALF.2
- At the lowest dose (0.25 mg/day) Divigel® eliminated about 70% of daily hot flashes by 12 weeks.2
- Efficacy studies were not required for approval of the 0.75 mg and 1.25 mg dose strengths; therefore, data on reduction in frequency and severity for these two strengths cannot be provided.

This was a 12-week, randomized, double-blind, placebo-controlled clinical trial of 488 post-menopausal women who had severe hot flash symptoms
Data remain significant from placebo at week 12.
- Divigel® reduced the severity of hot flashes by 67% at 12 Weeks (1 mg/day).2
- All dose strengths have been proven to reduce the severity of hot flashes.2
- 0.25 mg is not statistically significant until 7 weeks.2
- On Divigel® your patients may not only experience fewer hot flashes and night sweats over time but those symptoms may also be less severe.2
- Efficacy studies were not required for approval of the 0.75 mg and 1.25 mg dose strengths; therefore, data on reduction in frequency and severity for these two strengths cannot be provided.
MEAN SERUM ESTRADIOL CONCENTRATION [PG/ML]
MEAN SERUM ESTRADIOL CONCENTRATION [PG/ML] |
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- Divigel® sustained serum concentrations of estradiol over 24 hours.
- Divigel® offers 5 dosing options for individualized treatment.
- Only Divigel® offers the lowest dose of topical estrogen get or spray available for hot flashes (0.25mg/day estradiol)1
- Efficacy studies were not required for approval of the 0.75 mg and 1.25 mg dose strengths; therefore, data on reduction in frequency and severity for these two strengths cannot be provided.
DELIVERED THROUGH THE SKIN
Although the clinical significance has not been determined, estradiol from Divigel® does not undergo first pass metabolism.4,5
DIVIGEL® TOPICAL GEL





ORAL TREATMENTS









Effective Relief

Samples

Savings Offers

Dosing & Administration
REFERENCES
1. Orange Book: Approved Drug Products with Therapeutic equivalence Evaluations. U.S. Food & Drug Administration. Accessed February 13, 2020. https://www.accessdata.fda.gov/scripts/cder/ob/search_product.cfm
2. Hedrick RE, Ackerman RT, Koltun WD, Halvorsen MB, Lambrecht LJ. Transdermal estradiol gel 0.1% for the treatment of vasomotor symptoms in postmenopausal women. Menopause. 2009;16(1):132-140.
3. Divigel® [package insert]. Vertical Pharmaceuticals, LLC; 2019.
4. Goodman NF, Cobin RH, Ginzburg SB, Katz IA, Woode DE; American Association of Clinical Endocrinologists. American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the diagnosis and treatment of menopause. Endocr Pract. 2011;17(suppl 6):1-25.
5. Samsioe G. Transdermal hormone therapy: gels and patches. Climacteric. 2004;7(4):347-356.