Divigel® is available in 5 dosage strengths: 0.25 mg, 0.5 mg, 0.75 mg, 1.0 mg and 1.25 mg estradiol/day. This includes the lowest FDA-approved dose of transdermal estradiol gel or spray available.1

Start therapy with the 0.25 grams applied once daily on the skin of either the right or left upper thigh. Adjust the dose up to a maximum of 1.25 grams, as needed.

Application Instructions For Your Patients

Woman simply applying Divigel®.

Advise your patients to choose a convenient time to apply Divigel®, one that they can remember every day. For instance, suggest applying after their morning shower or at night before bed. It should easily become part of their daily personal care routine.

Before applying Divigel®, make certain the application site on the upper thigh is clean and dry, and has no cuts or scrapes.
Tear the foil packet and squeeze out the entire contents onto the skin of the upper thigh. Rub the gel on the upper thigh over an area about the size of two palms or a 5 x 7 photograph. (Alternate between left and right thigh each day.)
When done applying Divigel®, dispose of the empty packet and wash hands immediately to remove any remaining gel.
It’s important to take Divigel® once a day as directed. This will help your body sustain a more consistent level of estrogen to relieve your symptoms. Let the gel dry completely before dressing. Wait at least 1 hour before bathing or swimming. There is a potential risk for transdermal transmission of estradiol in Divigel® to another individual. To reduce the risk of transmission, advise patients to wash hands, avoid skin contact until gel is completely dried, and cover the application site.

Instructions if a Dose is Missed

If the next dose is MORE THAN 12 hours away, apply Divigel® dose and then resume normal schedule on the next day.

• Do not “double up” a dose to catch up.

If the next dose is LESS THAN 12 hours away, SKIP THE MISSED DOSE, and then resume normal schedule on the next day.


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1. Orange Book: Approved Drug Products with Therapeutic equivalence Evaluations. U.S. Food & Drug Administration. Accessed February 13, 2020. https://www.accessdata.fda.gov/scripts/cder/ob/search_product.cfm

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