Divigel® gives women a convenient solution for relief of vasomotor symptoms.

Divigel® is a fast-drying estradiol gel that is invisible, odorless and non-sticky when dry. It delivers highly concentrated estradiol at 0.1%, so only a small amount of gel is applied once daily to the upper thigh, the smallest application for plant-based estrogen gel.1-4

#1 Prescribed Gel with Plant-Based Estrogen5

Divigel® eliminated nearly 90% of vasomotor symptoms (hot flashes and night sweats) in 12 weeks with 1 mg/day.1

Plant-Based & Bioidentical
  • Estradiol, the active ingredient in Divigel®, comes from plants.
  • It is chemically identical to the estrogen naturally produced by your body before menopause.
Once-Daily Application
  • Once-daily application for all-day, all-night estradiol coverage.
  • Divigel® offers 3 dosage strengths, including the lowest FDA-approved dose (0.25 mg/day) of plant-based estradiol for effective relief of moderate to severe hot flashes.
Premeasured Packets
  • Divigel® comes in small packets that are portable, discreet, and easy to use at home or away.
  • Divigel® samples include a week of therapy and a travel case.
  • Divigel® is appropriate for active lifestyles and in hot and humid conditions, where patch adhesion can be problematic.
Concentrated and Easy to Apply
  • Divigel® is a concentrated gel that is applied to a small area on the upper thigh.
  • Alternate between left and right thigh each day.
Fast-Drying, Invisible Gel
  • Divigel® is a fast drying gel that leaves no sticky residue.
  • It’s invisible and odorless when dry. Nobody knows you’re wearing it.
  • There is a potential risk for transdermal transmission of estradiol in Divigel® to another individual. To reduce the risk of transmission, cover the applied area until Divigel® has completely dried.
Divigel® is Affordable
  • Divigel® has broad coverage on most insurance plans and is one of the lowest cost non-patch topical estrogen therapies.6
  • Eligible patients can enroll in the Patient Savings Program to save on 12 months of Divigel®.

Current American Congress of Obstetricians and Gynecologists (ACOG) and North American Menopause Society (NAMS) guidelines recommend using the lowest effective dose of estrogen, for the shortest duration of time, for treatment of vasomotor symptoms.7 Patients can be confident that Divigel® contains bioidentical 17β-estradiol derived from plant sources. 17β-estradiol is bioidentical to the estrogen produced naturally in a woman’s body prior to menopause. “Natural” or compounded estradiol products are NOT FDA-approved7.

REFERENCES
1. Divigel® [package insert]. Vertical Pharmaceuticals, LLC; 2014. 2. EstroGel® [package insert]. Herndon, VA: ASCEND Therapeutics, Inc.; 2014. 3. Elestrin® [package insert]. Somerset, NJ: Meda Pharmaceuticals™; 2014. 4. Evamist® [package insert]. Minneapolis, MN: Perrigo®; 2015. 5. IMS data, 2017. 6. Data on file, Vertical Pharmaceuticals, LLC, Bridgewater, NJ. 7. American College of Obstetricians and Gynecologists. Patient Education Fact Sheet: Hormone Therapy. American College of Obstetricians and Gynecologists website. https://www.acog.org/Patients/FAQs/Hormone-Therapy Published April 2015. Accessed May 2, 2017. 8. Data on file. Vertical Pharmaceuticals, LLC; 2017.

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